When it comes to building a kidney, only nature possesses the complete set of blueprints. But a USC-led team of scientists has managed to borrow some of nature’s pages through a comprehensive analysis of how kidneys form their filtering units, known as nephrons. Published in the journal Developmental Cell, the study from Andy McMahon’s lab…Continue Reading USC-led study traces the blueprints for how human kidneys form their filtering units
Year: 2021
The same cell type can help or hinder repair after acute kidney injury
The USC Stem Cell laboratory of Andy McMahon has identified a type of injured cell that might contribute to the transition from an acute kidney injury to chronic kidney disease, as described in a new study published in the Proceedings of the National Academy of Sciences (PNAS). The same issue of PNAS also features an…Continue Reading The same cell type can help or hinder repair after acute kidney injury
USC Stem Cell scientists make big progress in building mini-kidneys
A team of scientists at the Keck School of Medicine of USC has created what could be a key building block for assembling a synthetic kidney. In a new study in Nature Communications, Zhongwei Li and his colleagues describe how they can generate rudimentary kidney structures, known as organoids, that resemble the collecting duct system…Continue Reading USC Stem Cell scientists make big progress in building mini-kidneys
McMahon Lab study identifies molecular “switch” that turns precursors into kidney cells
Kidney development is a balancing act between the self-renewal of stem and progenitor cells to maintain and expand their numbers, and the differentiation of these cells into more specialized cell types. In a new study in the journal eLife from Andy McMahon’s laboratory in the Department of Stem Cell Biology and Regenerative Medicine at the…Continue Reading McMahon Lab study identifies molecular “switch” that turns precursors into kidney cells
PhD student Tracy Tran: Celebrating the journey of a budding developmental biologist
By Angelina Girgis As a child in Vietnam, Tracy Tran helped her family run a small business importing porcelain products from China and assumed she would follow in their footsteps. Neither of her parents had a college degree, and they worked very hard to support Tran and her sister. Once her parents finally had the…Continue Reading PhD student Tracy Tran: Celebrating the journey of a budding developmental biologist