A group of essential signaling molecules known as the Wnt pathway emerged early in the evolution of multicellular life. Scientists have been studying Wnt actions for four decades to comprehend its complex roles in development and disease. In development of the mammalian kidney, USC Stem Cell scientists from Andy McMahon’s lab undertook a pair of…Continue Reading Wnt happens in kidney development?
Year: 2024
New study shows cells get involved in unhealthy relationships after acute kidney injury (AKI) in mice
A study published in Nature Communications provides new insight into how damaged cells interact within disease-promoting microenvironments following acute kidney injury, or AKI. With limited treatment options, AKI frequently progresses to chronic kidney disease (CKD), which affects more than 1 in 7 U.S. adults—an estimated 37 million people. The new findings may contribute to future…Continue Reading New study shows cells get involved in unhealthy relationships after acute kidney injury (AKI) in mice
USC Stem Cell study maps how genes instruct kidneys to develop differently in mice and humans
How similar is kidney development in humans and in the lab mice that form the foundation of basic medical research? In a new study published in Developmental Cell, USC Stem Cell scientists probe this question by comparing the activity and regulation of the genes that drive kidney development in lab mice and humans. “While we…Continue Reading USC Stem Cell study maps how genes instruct kidneys to develop differently in mice and humans